This treatise investigated the predictive value of stress associated and other influence factors on concentrations of stem cell populations in umbilical cord blood. Therefore 1,192 newborns have been evaluated for different neonatal and maternal parameters as well as for their cord blood concentrations of CD34-positive and mononuclear cells. The postpartal cord blood pH correlated negatively with concentrations of both cell populations, newborns with a pH below 7.2 showed significantly higher cell concentrations. Newborns to smoking mothers were found to have significantly lower cell counts. Higher cell counts of mononuclear cells have been found with spontaneous, forceps and ventouse deliveries when compared with caesarean sections. Newborns with an Apgar-score ≤ 7 showed higher concentrations of CD34-positive cells compared to newborns with physiologic Apgar-scores ≥ 8. Those results demonstrate a relation between peripartal parameters and stem cell counts, which may help to optimize the stem cell yield from cord blood and alleviate the selection of newborns for umbilical cord blood donations in the future.     «

This treatise investigated the predictive value of stress associated and other influence factors on concentrations of stem cell populations in umbilical cord blood. Therefore 1,192 newborns have been evaluated for different neonatal and maternal parameters as well as for their cord blood concentrations of CD34-positive and mononuclear cells. The postpartal cord blood pH correlated negatively with concentrations of both cell populations, newborns with a pH below 7.2 showed significantly higher c...     »