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- Original title:
- Reduced Molecular Flavins as Single Electron Transfer Catalysts: Cyclization of Barbituric Acid Derivatives
- Translated title:
- Reduzierte Molekulare Flavine als Einelektronen-Transfer-Katalysatoren: Cyclisierung von Barbitursäure-Derivaten
- Author:
- Foja, Richard
- Year:
- 2024
- Document type:
- Dissertation
- Faculty/School:
- TUM School of Natural Sciences
- Institution:
- Lehrstuhl für Organische Chemie I (Prof. Bach)
- Advisor:
- Storch, Golo T. B. (Dr.)
- Referee:
- Storch, Golo T. B. (Dr.); Zeymer, Cathleen (Prof. Dr.)
- Language:
- en
- Subject group:
- CHE Chemie
- Keywords:
- Organic Chemistry; Photochemistry; Flavins; Synthesis; Catalysis
- TUM classification:
- CHE 600
- Abstract:
- We report the application of reduced flavins in the photoreductive cyclization of barbituric acid derivatives. Optimization of the reaction conditions was performed with a novel reduced flavin that evades oxidation under air. Different electron acceptors were successfully employed. Orthogonal conversion of barbituric acid derivatives and reduction of O-methyl oximes which were resistant to samarium (II) iodide reduction demonstrate the additional utility of the novel reduced flavin method.
- Translated abstract:
- Wir berichten die Anwendung reduzierter Flavine in der photoreduktiven Cyclisierung von Barbitursäurederivaten. Optimierung der Reaktionsbedingungen erfolgte anhand eines neuartigen reduzierten Flavins, welches gegenüber Luft stabil ist. Verschiedene Elektronenakzeptoren wurden erfolgreich reduziert. Orthogonale Reaktionen von Barbitursäurederivaten und Reduktion von O Methyloximen, welche nicht mit SmI2 reagieren, demonstrieren die Nützlichkeit der neuentwickelten Methode reduzierter Flavine.
- WWW:
- https://mediatum.ub.tum.de/?id=1747415
- Date of submission:
- 26.06.2024
- Oral examination:
- 26.07.2024
- File size:
- 6588276 bytes
- Pages:
- 70
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20240726-1747415-1-1
- Last change:
- 12.08.2024
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