Analysis of small heat shock proteins and their interaction with substrate proteins

Kreuzeder, Marina Angelika

User: Guest

Chemie

Back
Back to start of result list
Permanent link for displayed object

If you experience problems opening the document, please try this link.

Original title:: Analysis of small heat shock proteins and their interaction with substrate proteins
Translated title:: Analyse kleiner Hitzeschockproteine und deren Interaktion mit Sustratproteinen
Author:: Kreuzeder, Marina Angelika
Year:: 2017
Document type:: Dissertation
Faculty/School:: Fakultät für Chemie
Advisor:: Buchner, Johannes (Prof. Dr.)
Referee:: Buchner, Johannes (Prof. Dr.); Sattler, Michael (Prof. Dr.)
Language:: en
Subject group:: CHE Chemie
TUM classification:: CHE 800d; CIT 900d
Abstract:: In the present thesis, structural analysis of Hsp26 from S. cerevisiae was performed with a focus on the mode of dimerization. Furthermore, phosphomimetic Hsp26 mutants were analyzed revealing phosphorylation as a potential regulatory mechanism for Hsp26. In addition, the substrate spectra of the human proteins HspB1 to HspB7 and of the Hsp16 protein core family from C. elegans were investigated by co-imunoprecipitation and mass spectrometric approaches.
Translated abstract:: In der vorliegenden Arbeit wurde Hsp26 aus S. cerevisiae strukturell, vor allem hinsichtlich der Art der Dimerisierung, untersucht. Des Weiteren wurden phophomimetische Hsp26 Mutanten analysiert und die mögliche Regulation von Hsp26 durch Phosphorylierung aufgezeigt. Außerdem wurden die Substratspektren der humanen Proteine HspB1 bis HspB7 und der Hsp16 Kernfamilie aus C. elegans mithilfe von Co-Immunopräzipitation und massenspektrometrischen Analysen bestimmt.
WWW:: https://mediatum.ub.tum.de/?id=1385600
Date of submission:: 18.09.2017
Oral examination:: 13.11.2017
File size:: 13177712 bytes
Pages:: 195
Urn (citeable URL):: https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20171113-1385600-1-0
Last change:: 13.11.2019
BibTeX