Translated abstract:
The cGMP-dependent protein kinase type I (cGKI) is a potential mediator of NO/cGMP effects in smooth muscle cells (SMCs), but the molecular mechanisms of cGKI action, particularly the specific roles of the two cGKI isoforms, cGKI-alpha and cGKI-beta, are poorly understood. Here new transgenic mouse lines were created to clarify the (patho-)physiological relevance of cGKI isoforms in SMCs.