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Titel:

Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Raj Murthi, Sarala; Petry, Andreas; Shashikadze, Bachuki; Stöckl, Jan B; Schmid, Manuel; Santamaria, Gianluca; Klingel, Karin; Kračun, Damir; Chen, Xinpei; Bauer, Sabine; Schmitt, Joachim P; Flenkenthaler, Florian; Gorham, Josh; Toepfer, Christopher N; Potěšil, David; Hruška, Pavel; Zdráhal, Zbyněk; Mayer, Zsuzsanna; Klop, Mathieu; Lehmann, Luisa; Qin, Yishi; Papanakli, Laura; Spielmann, Nadine; Moretti, Alessandra; Fröhlich, Thomas; Ewert, Peter; Holdenrieder, Stefan; Seidman, Jonathan G; Seidm...     »
Abstract:
Hypertrophic cardiomyopathy (HCM) caused by autosomal-dominant mutations in genes coding for structural sarcomeric proteins, is the most common inherited heart disease. HCM is associated with myocardial hypertrophy, fibrosis and ventricular dysfunction. Hypoxia-inducible transcription factor-1α (Hif-1α) is the central master regulators of cellular hypoxia response and associated with HCM. Yet its exact role remains to be elucidated. Therefore, the effect of a cardiomyocyte-specific Hif-1a knocko...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2025
Band / Volume:
15
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41598-025-85187-9
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/39820339
Print-ISSN:
2045-2322
TUM Einrichtung:
1121; 1141; Klinik für Kinderkardiologie und angeborene Herzfehler (DHM) (Prof. Ewert); Professur für Regenerative Medizin bei Kardiovaskulären Erkrankungen (Prof. Moretti)
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