Tumor budding and lymphovascular invasion as prognostic factors in p16-positive oropharyngeal squamous cell carcinomas.

Stögbauer, Fabian; Wirth, Markus; Lauterbach, Maren; Wollenberg, Barbara; Schmidl, Benedikt; Hoch, Cosima C; Ourailidis, Iordanis; Hess, Jochen; Eckstein, Markus; Hartmann, Arndt; Iro, Heinrich; Gostian, Antoniu-Oreste; Balk, Matthias; Jesinghaus, Moritz; Ribbat-Idel, Julika; Sailer, Verena-Wilbeth; Perner, Sven; Bruchhage, Karl-Ludwig; Hoffmann, Markus; Lükewille, Lukas; Stuhlmann-Laeisz, Christiane Maria; Röcken, Christoph; Mogler, Carolin; Budczies, Jan; Boxberg, Melanie

doi:10.1038/s41416-024-02912-3

Benutzer: Gast

2025

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Titel:: Tumor budding and lymphovascular invasion as prognostic factors in p16-positive oropharyngeal squamous cell carcinomas.
Dokumenttyp:: Journal Article; Multicenter Study
Autor(en):: Stögbauer, Fabian; Wirth, Markus; Lauterbach, Maren; Wollenberg, Barbara; Schmidl, Benedikt; Hoch, Cosima C; Ourailidis, Iordanis; Hess, Jochen; Eckstein, Markus; Hartmann, Arndt; Iro, Heinrich; Gostian, Antoniu-Oreste; Balk, Matthias; Jesinghaus, Moritz; Ribbat-Idel, Julika; Sailer, Verena-Wilbeth; Perner, Sven; Bruchhage, Karl-Ludwig; Hoffmann, Markus; Lükewille, Lukas; Stuhlmann-Laeisz, Christiane Maria; Röcken, Christoph; Mogler, Carolin; Budczies, Jan; Boxberg, Melanie
Abstract:: BACKGROUND: We aimed to validate the prognostic significance of tumor budding (TB) in p16-positive oropharyngeal squamous cell carcinomas (OPSCC). METHODS: We analyzed digitized H&E-stained slides from a multicenter cohort of five large university centers consisting of n = 275 cases of p16-positive OPSCC. We evaluated TB along with other histological parameters (morphology, tumor-stroma-ratio, lymphovascular invasion (LVI), perineural invasion) and calculated survival outcomes using both univariate and multivariate analyses. RESULTS: TB was identified as an independent prognostic parameter, with TB-high cases showing inferior outcomes in univariate (HR: 3.08, 95%-CI: 1.71-5.54) and multivariate analyses (HR: 4.03, 95%-CI: 1.65-9.83). Similarly, LVI remained an independent prognostic factor (HR: 3.00, 95%-CI: 1.22-7.38). A combined classification including TB and LVI stratified cases into low-, intermediate- and high-risk categories. We could not detect correlations between TB and the number of lymph node metastases or between TB and an extracapsular extension of lymph node metastases. CONCLUSIONS: In addition to LVI, we could identify TB as an independent prognostic factor in p16-positive OPSCC in this multicenter study cohort. Thus, evaluating TB along with LVI in a combined scheme for prognostication might help to establish a more personalized treatment regimen for patients with p16-positive OPSCC. «
BACKGROUND: We aimed to validate the prognostic significance of tumor budding (TB) in p16-positive oropharyngeal squamous cell carcinomas (OPSCC). METHODS: We analyzed digitized H&E-stained; slides from a multicenter cohort of five large university centers consisting of n = 275 cases of p16-positive OPSCC. We evaluated TB along with other histological parameters (morphology, tumor-stroma-ratio, lymphovascular invasion (LVI), perineural invasion) and calculated survival outcomes using both univariate and m... »
Zeitschriftentitel:: Br J Cancer
Jahr:: 2025
Band / Volume:: 132
Heft / Issue:: 2
Seitenangaben Beitrag:: 212-221
Volltext / DOI:: doi:10.1038/s41416-024-02912-3
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/39613843
Print-ISSN:: 0007-0920
TUM Einrichtung:: Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.)
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mediaTUM Gesamtbestand Hochschulbibliographie 2025 Schools TUM School of Medicine and Health Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.)

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Preclinical Medicine Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.)2025