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Title:

The mesencephalic locomotor region recruits V2a reticulospinal neurons to drive forward locomotion in larval zebrafish.

Document type:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Carbo-Tano, Martin; Lapoix, Mathilde; Jia, Xinyu; Thouvenin, Olivier; Pascucci, Marco; Auclair, François; Quan, Feng B; Albadri, Shahad; Aguda, Vernie; Farouj, Younes; Hillman, Elizabeth M C; Portugues, Ruben; Del Bene, Filippo; Thiele, Tod R; Dubuc, Réjean; Wyart, Claire
Abstract:
The mesencephalic locomotor region (MLR) is a brain stem area whose stimulation triggers graded forward locomotion. How MLR neurons recruit downstream vsx2+ (V2a) reticulospinal neurons (RSNs) is poorly understood. Here, to overcome this challenge, we uncovered the locus of MLR in transparent larval zebrafish and show that the MLR locus is distinct from the nucleus of the medial longitudinal fasciculus. MLR stimulations reliably elicit forward locomotion of controlled duration and frequency. MLR...     »
Journal title abbreviation:
Nat Neurosci
Year:
2023
Journal volume:
26
Journal issue:
10
Pages contribution:
1775-1790
Fulltext / DOI:
doi:10.1038/s41593-023-01418-0
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37667039
Print-ISSN:
1097-6256
TUM Institution:
Institut für Neurowissenschaften (Prof. Konnerth)
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