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Title:

Immunomodulatory leptin receptor+ sympathetic perineurial barrier cells protect against obesity by facilitating brown adipose tissue thermogenesis.

Document type:
Journal Article
Author(s):
Haberman, Emma R; Sarker, Gitalee; Arús, Bernardo A; Ziegler, Karin A; Meunier, Sandro; Martínez-Sánchez, Noelia; Freibergerová, Eliška; Yilmaz-Özcan, Sinem; Fernández-González, Iara; Zentai, Chloe; O'Brien, Conan J O; Grainger, David E; Sidarta-Oliveira, Davi; Chakarov, Svetoslav; Raimondi, Andrea; Iannacone, Matteo; Engelhardt, Stefan; López, Miguel; Ginhoux, Florent; Domingos, Ana I
Abstract:
Adipose tissues (ATs) are innervated by sympathetic nerves, which drive reduction of fat mass via lipolysis and thermogenesis. Here, we report a population of immunomodulatory leptin receptor-positive (LepR+) sympathetic perineurial barrier cells (SPCs) present in mice and humans, which uniquely co-express Lepr and interleukin-33 (Il33) and ensheath AT sympathetic axon bundles. Brown ATs (BATs) of mice lacking IL-33 in SPCs (SPCΔIl33) had fewer regulatory T (Treg) cells and eosinophils, resultin...     »
Journal title abbreviation:
Immunity
Year:
2024
Journal volume:
57
Journal issue:
1
Pages contribution:
141-152.e5
Fulltext / DOI:
doi:10.1016/j.immuni.2023.11.006
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/38091996
Print-ISSN:
1074-7613
TUM Institution:
Institut für Pharmakologie und Toxikologie (Prof. Engelhardt)
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