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Titel:

Surface plasmon resonance assays for the therapeutic drug monitoring of infliximab indicate clinical relevance of anti-infliximab antibody binding properties.

Dokumenttyp:
Journal Article
Autor(en):
Grasmeier, Melina K; Weber, Susanne; Treiber, Matthias; Thaler, Markus A; Luppa, Peter B
Abstract:
OBJECTIVES: The therapeutic antibody infliximab (IFX) has improved the life quality of numerous autoinflammatory disease patients. However, IFX can trigger the generation of anti-drug antibodies (ADA), whose optimal evaluation and management are currently subject of controversial discussions. We present two novel surface plasmon resonance (SPR) biosensor assays for therapeutic drug monitoring of IFX and characterization of ADA and investigated the diagnostic value of ADA binding properties. METH...     »
Zeitschriftentitel:
Clin Chem Lab Med
Jahr:
2023
Band / Volume:
61
Heft / Issue:
7
Seitenangaben Beitrag:
1255-1265
Volltext / DOI:
doi:10.1515/cclm-2022-0949
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36753693
Print-ISSN:
1434-6621
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie (Prof. Ruland); Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid)
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