Raster Scan Optoacoustic Mesoscopy for detecting microvascular complications in diabetes mellitus: A narrative brief review.

Pantazopoulos, Dimitrios; Gouveri, Evanthia; Ntziachristos, Vasilis; Papanas, Nikolaos

doi:10.1016/j.diabres.2025.112095

Benutzer: Gast

Preclinical Medicine

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Titel:: Raster Scan Optoacoustic Mesoscopy for detecting microvascular complications in diabetes mellitus: A narrative brief review.
Dokumenttyp:: Journal Article; Review
Autor(en):: Pantazopoulos, Dimitrios; Gouveri, Evanthia; Ntziachristos, Vasilis; Papanas, Nikolaos
Abstract:: Diabetes mellitus (DM) may lead to microvascular and macrovascular complications. Screening for these complications is crucial, and so non-invasive methods with high-dissemination potential are needed. Diabetic peripheral neuropathy (DPN) is particularly challenging to screen due to the lack of reliable clinical markers and endpoints. In this context, Raster Scan Optoacoustic Mesoscopy (RSOM) emerges as a highly promising technique that offers hybrid, non-invasive imaging of optical absorption using light-induced ultrasound waves within tissue without the use of contrast agents. RSOM provides high-resolution visualisation of micro-vasculature and other tissue structures along with functional information. The technique has already assessed microvasculature loss as a function of diabetes progression and used it to characterise DPN severity. RSOM has also shown that cutaneous vessels in the mesoscopic range (mean diameters of 30-40 µm) are most prominently affected by DM and that the mean number of cutaneous vessels was lower in subjects with DM than in healthy participants (p < 0.001 and p < 0.05, respectively). Although experience is still limited, we present an overview of the novel technique in relation to its potential for detecting early DM onset and development of microvascular complications.
Zeitschriftentitel:: Diabetes Res Clin Pract
Jahr:: 2025
Band / Volume:: 222
Volltext / DOI:: doi:10.1016/j.diabres.2025.112095
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/40073947
Print-ISSN:: 0168-8227
TUM Einrichtung:: Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Preclinical Medicine Weitere Lehrstühle und Professuren Preclinical Medicine Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)2025

mediaTUM Gesamtbestand Hochschulbibliographie 2025 Schools TUM School of Medicine and Health Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)