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Title:

Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Bayerl, Felix; Meiser, Philippa; Donakonda, Sainitin; Hirschberger, Anna; Lacher, Sebastian B; Pedde, Anna-Marie; Hermann, Chris D; Elewaut, Anais; Knolle, Moritz; Ramsauer, Lukas; Rudolph, Thomas J; Grassmann, Simon; Öllinger, Rupert; Kirchhammer, Nicole; Trefny, Marcel; Anton, Martina; Wohlleber, Dirk; Höchst, Bastian; Zaremba, Anne; Krüger, Achim; Rad, Roland; Obenauf, Anna C; Schadendorf, Dirk; Zippelius, Alfred; Buchholz, Veit R; Schraml, Barbara U; Böttcher, Jan P
Abstract:
Type 1 conventional dendritic cells (cDC1s) are critical for anti-cancer immunity. Protective anti-cancer immunity is thought to require cDC1s to sustain T cell responses within tumors, but it is poorly understood how this function is regulated and whether its subversion contributes to immune evasion. Here, we show that tumor-derived prostaglandin E2 (PGE2) programmed a dysfunctional state in intratumoral cDC1s, disabling their ability to locally orchestrate anti-cancer CD8+ T cell responses. Me...     »
Journal title abbreviation:
Immunity
Year:
2023
Journal volume:
56
Journal issue:
6
Pages contribution:
1341-1358.e11
Fulltext / DOI:
doi:10.1016/j.immuni.2023.05.011
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37315536
Print-ISSN:
1074-7613
TUM Institution:
594; Institut für Experimentelle Onkologie und Therapieforschung; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene (Prof. Busch); Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad); Roman Herzog Comprehensive Cancer Center
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