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Title:

Phenotype screens of murine pancreatic cancer identify a Tgf-α-Ccl2-paxillin axis driving human-like neural invasion.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Wang, Xiaobo; Istvanffy, Rouzanna; Ye, Linhan; Teller, Steffen; Laschinger, Melanie; Diakopoulos, Kalliope N; Görgülü, Kıvanç; Li, Qiaolin; Ren, Lei; Jäger, Carsten; Steiger, Katja; Muckenhuber, Alexander; Vilne, Baiba; Çifcibaşı, Kaan; Mota Reyes, Carmen; Yurteri, Ümmügülsüm; Kießler, Maximilian; Gürçınar, Ibrahim H; Sugden, Maya M; Yıldızhan, Saliha Elif; Sezerman, Osman Ugur; Çilingir, Sümeyye; Süyen, Güldal; Reichert, Maximilian; Schmid, Roland M; Bärthel, Stefanie; Öllinger, Rupert; Krüger,...     »
Abstract:
Solid cancers like pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer, frequently exploit nerves for rapid dissemination. This neural invasion (NI) is an independent prognostic factor in PDAC, but insufficiently modeled in genetically engineered mouse models (GEMM) of PDAC. Here, we systematically screened for human-like NI in Europe's largest repository of GEMM of PDAC, comprising 295 different genotypes. This phenotype screen uncovered 2 GEMMs of PDAC with human-like NI, whic...     »
Journal title abbreviation:
J Clin Invest
Year:
2023
Journal volume:
133
Journal issue:
21
Fulltext / DOI:
doi:10.1172/JCI166333
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37607005
Print-ISSN:
0021-9738
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Chirurgie (Prof. Friess); Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid); Lehrstuhl für Tumormetabolismus (Prof. Algül); Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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