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Titel:

Phosphatidylserine-positive extracellular vesicles boost effector CD8+ T cell responses during viral infection.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Rausch, Lisa; Flaskamp, Lavinia; Ashokkumar, Ashretha; Trefzer, Anne; Ried, Christine; Buchholz, Veit R; Obst, Reinhard; Straub, Tobias; Brocker, Thomas; Kranich, Jan
Abstract:
CD8+ T cells are crucial for the clearance of viral infections. During the acute phase, proinflammatory conditions increase the amount of circulating phosphatidylserine+ (PS) extracellular vesicles (EVs). These EVs interact especially with CD8+ T cells; however, it remains unclear whether they can actively modulate CD8+ T cell responses. In this study, we have developed a method to analyze cell-bound PS+ EVs and their target cells in vivo. We show that EV+ cell abundance increases during viral...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2023
Band / Volume:
120
Heft / Issue:
16
Volltext / DOI:
doi:10.1073/pnas.2210047120
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37040405
Print-ISSN:
0027-8424
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene (Prof. Busch)
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