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- Titel:
Efficacy of ultrasound assisted catheter-directed thrombolysis compared to catheter-directed thrombolysis in vitro.
- Dokumenttyp:
- Journal Article
- Autor(en):
- Nadjiri, Jonathan; Kierse, Anna; Sendlbeck, Melanie; Janssen, Agnes; Geith, Tobias; Waggershauser, Tobias; Paprottka, Philipp M
- Abstract:
- BACKGROUND: Catheter-directed thrombolysis (CDT) is an effective and safe endovascular method used in critical limb ischemia and many other thromboembolic events. Ultrasound-assisted catheter-directed thrombolysis (US-CDT) is an emerging technique considered to accelerate thrombolysis and therefore is supposed to improve outcome. PURPOSE: To evaluate the efficacy of US-CDT in comparison to standard CDT in vitro. MATERIAL AND METHODS: A total of 69 sets of human venous blood were evaluated, each comprising a tube just treated with CDT, a tube treated with US-CDT, and a control tube. All tubes were kept under physiological conditions. Except for the controls, in all tubes 5 mg of tissue-type plasminogen activator was administered over the predetermined treatment interval. Thrombus mass was weighted at the end of the lysis intervals at 6 h or 24 h, respectively. RESULTS: CDT led to a mean thrombus reduction of 32% and ultrasound-assisted lysis led to a mean thrombus reduction of 41% (P < 0.001 for both). Thrombus reduction was significantly higher after US-CDT compared to CDT (P = 0.001). The better efficacy of US-CDT was mostly already apparent at early phases during thrombolysis and did further mildly increase over time (r = 0.24; P = 0.047). CONCLUSION: In vitro US-CDT is significantly superior to standard CDT; this effect is apparent at an early timepoint of lysis and slightly further increases over time.
- Zeitschriftentitel:
- Acta Radiol
- Jahr:
- 2023
- Band / Volume:
- 64
- Heft / Issue:
- 1
- Seitenangaben Beitrag:
- 119-124
- Volltext / DOI:
- doi:10.1177/02841851211061440
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/34866428
- Print-ISSN:
- 0284-1851
- TUM Einrichtung:
- Professur für Interventionelle Radiologie (Prof. Paprottka)
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