In addition to the already established and conventional X-ray absorption contrast, grating-based Talbot-Lau interferometry provides the opportunity to introduce complementary contrast modalities of phase contrast and dark-field imaging with lab-based X-ray tubes. This thesis aims for further technical development and optimization of a preclinical in-vivo phase contrast and dark-field microCT. Moreover, the potential of in-vivo phase-contrast radiography and dark-field computed tomography for the detection of pulmonary and bronchial disorders in mice is investigated.
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In addition to the already established and conventional X-ray absorption contrast, grating-based Talbot-Lau interferometry provides the opportunity to introduce complementary contrast modalities of phase contrast and dark-field imaging with lab-based X-ray tubes. This thesis aims for further technical development and optimization of a preclinical in-vivo phase contrast and dark-field microCT. Moreover, the potential of in-vivo phase-contrast radiography and dark-field computed tomography for the...
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