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Title:

CCL17 Promotes Colitis-Associated Tumorigenesis Dependent on the Microbiota.

Document type:
Journal Article
Author(s):
Metzger, Rebecca; Winter, Lis; Bouznad, Nassim; Garzetti, Debora; von Armansperg, Benedikt; Rokavec, Matjaz; Lutz, Konstantin; Schäfer, Yvonne; Krebs, Sabrina; Winheim, Elena; Friedrich, Verena; Matzek, Dana; Öllinger, Rupert; Rad, Roland; Stecher, Bärbel; Hermeking, Heiko; Brocker, Thomas; Krug, Anne B
Abstract:
Colorectal cancer is one of the most common cancers and a major cause of mortality. Proinflammatory and antitumor immune responses play critical roles in colitis-associated colon cancer. CCL17, a chemokine of the C-C family and ligand for CCR4, is expressed by intestinal dendritic cells in the steady state and is upregulated during colitis in mouse models and inflammatory bowel disease patients. In this study, we investigated the expression pattern and functional relevance of CCL17 for colitis-a...     »
Journal title abbreviation:
J Immunol
Year:
2022
Journal volume:
209
Journal issue:
11
Pages contribution:
2227-2238
Fulltext / DOI:
doi:10.4049/jimmunol.2100867
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36426975
Print-ISSN:
0022-1767
TUM Institution:
Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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