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Title:

The OTUD6B-LIN28B-MYC axis determines the proliferative state in multiple myeloma.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Paulmann, Carmen; Spallek, Ria; Karpiuk, Oleksandra; Heider, Michael; Schäffer, Isabell; Zecha, Jana; Klaeger, Susan; Walzik, Michaela; Öllinger, Rupert; Engleitner, Thomas; Wirth, Matthias; Keller, Ulrich; Krönke, Jan; Rudelius, Martina; Kossatz, Susanne; Rad, Roland; Kuster, Bernhard; Bassermann, Florian
Abstract:
Deubiquitylases (DUBs) are therapeutically amenable components of the ubiquitin machinery that stabilize substrate proteins. Their inhibition can destabilize oncoproteins that may otherwise be undruggable. Here, we screened for DUB vulnerabilities in multiple myeloma, an incurable malignancy with dependency on the ubiquitin proteasome system and identified OTUD6B as an oncogene that drives the G1/S-transition. LIN28B, a suppressor of microRNA biogenesis, is specified as a bona fide cell cycle-sp...     »
Journal title abbreviation:
EMBO J
Year:
2022
Journal volume:
41
Journal issue:
20
Fulltext / DOI:
doi:10.15252/embj.2022110871
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36059274
Print-ISSN:
0261-4189
TUM Institution:
Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie; Klinik und Poliklinik für Nuklearmedizin; Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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