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Titel:

The OTUD6B-LIN28B-MYC axis determines the proliferative state in multiple myeloma.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Paulmann, Carmen; Spallek, Ria; Karpiuk, Oleksandra; Heider, Michael; Schäffer, Isabell; Zecha, Jana; Klaeger, Susan; Walzik, Michaela; Öllinger, Rupert; Engleitner, Thomas; Wirth, Matthias; Keller, Ulrich; Krönke, Jan; Rudelius, Martina; Kossatz, Susanne; Rad, Roland; Kuster, Bernhard; Bassermann, Florian
Abstract:
Deubiquitylases (DUBs) are therapeutically amenable components of the ubiquitin machinery that stabilize substrate proteins. Their inhibition can destabilize oncoproteins that may otherwise be undruggable. Here, we screened for DUB vulnerabilities in multiple myeloma, an incurable malignancy with dependency on the ubiquitin proteasome system and identified OTUD6B as an oncogene that drives the G1/S-transition. LIN28B, a suppressor of microRNA biogenesis, is specified as a bona fide cell cycle-sp...     »
Zeitschriftentitel:
EMBO J
Jahr:
2022
Band / Volume:
41
Heft / Issue:
20
Volltext / DOI:
doi:10.15252/embj.2022110871
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36059274
Print-ISSN:
0261-4189
TUM Einrichtung:
Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie; Klinik und Poliklinik für Nuklearmedizin; Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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