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Titel:

IL-24 intrinsically regulates Th17 cell pathogenicity in mice.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Sie, Christopher; Kant, Ravi; Peter, Christian; Muschaweckh, Andreas; Pfaller, Monika; Nirschl, Lucy; Moreno, Helena Domínguez; Chadimová, Tereza; Lepennetier, Gildas; Kuhlmann, Tanja; Öllinger, Rupert; Engleitner, Thomas; Rad, Roland; Korn, Thomas
Abstract:
In certain instances, Th17 responses are associated with severe immunopathology. T cell-intrinsic mechanisms that restrict pathogenic effector functions have been described for type 1 and 2 responses but are less well studied for Th17 cells. Here, we report a cell-intrinsic feedback mechanism that controls the pathogenicity of Th17 cells. Th17 cells produce IL-24, which prompts them to secrete IL-10. The IL-10-inducing function of IL-24 is independent of the cell surface receptor of IL-24 on Th1...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2022
Band / Volume:
219
Heft / Issue:
8
Volltext / DOI:
doi:10.1084/jem.20212443
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35819408
Print-ISSN:
0022-1007
TUM Einrichtung:
Molekulare Immunologie (Prof. Knolle); Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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