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Title:

Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells.

Document type:
Journal Article
Author(s):
Siow, Wei Xiong; Kabiri, Yaschar; Tang, Rachel; Chao, Yu-Kai; Plesch, Eva; Eberhagen, Carola; Flenkenthaler, Florian; Fröhlich, Thomas; Bracher, Franz; Grimm, Christian; Biel, Martin; Zischka, Hans; Vollmar, Angelika M; Bartel, Karin
Abstract:
Liver cancers, including hepatocellular carcinoma (HCC), are the second leading cause of cancer death worldwide, and novel therapeutic strategies are still highly needed. Recently, the endolysosomal cation channel TRPML1 (also known as MCOLN1) has gained focus in cancer research because it represents an interesting novel target. We utilized the recently developed isoform-selective TRPML1 activator ML1-SA1 and the CRISPR/Cas9 system to generate tools for overactivation and loss-of-function studie...     »
Journal title abbreviation:
J Cell Sci
Year:
2022
Journal volume:
135
Journal issue:
6
Fulltext / DOI:
doi:10.1242/jcs.259455
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35274126
Print-ISSN:
0021-9533
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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