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Titel:

Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Bolik, Julia; Krause, Freia; Stevanovic, Marija; Gandraß, Monja; Thomsen, Ilka; Schacht, Sarah-Sophie; Rieser, Eva; Müller, Miryam; Schumacher, Neele; Fritsch, Jürgen; Wichert, Rielana; Galun, Eithan; Bergmann, Juri; Röder, Christian; Schafmayer, Clemens; Egberts, Jan-Hendrik; Becker-Pauly, Christoph; Saftig, Paul; Lucius, Ralph; Schneider-Brachert, Wulf; Barikbin, Roja; Adam, Dieter; Voss, Matthias; Hitzl, Wolfgang; Krüger, Achim; Strilic, Boris; Sagi, Irit; Walczak, Henning; Rose-John, Stefan;...     »
Abstract:
Metastasis is the major cause of death in cancer patients. Circulating tumor cells need to migrate through the endothelial layer of blood vessels to escape the hostile circulation and establish metastases at distant organ sites. Here, we identified the membrane-bound metalloprotease ADAM17 on endothelial cells as a key driver of metastasis. We show that TNFR1-dependent tumor cell-induced endothelial cell death, tumor cell extravasation, and subsequent metastatic seeding is dependent on the activ...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2022
Band / Volume:
219
Heft / Issue:
1
Volltext / DOI:
doi:10.1084/jem.20201039
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34919140
Print-ISSN:
0022-1007
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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