We report on a 62 year-old male patient who presented at our hospital for a second opinion 2 with a rising PSA level of 23 ng/dl. He already underwent two transrectal biopsies (2013 and 3 2015) of the prostate and also a transurethral resection of the prostate (2016) with benign 4 results in histology reports. The patient underwent hybrid imaging of the prostate consisting 5 of multiparametric magnetic resonance imaging (mpMR) in combination with positron 6 emission tomography (PET) utilizing a specific tracer directed against the prostate-specific 7 membrane antigen (PSMA; 68Ga-HBED-CC-PSMA) for further evaluation. Imaging revealed 8 a PI-RADS 4 lesion with strong PSMA positivity on the left anterior lobe (Fig. 1). A transrectal 9 PSMA PET/MR fusion biopsy of the prostate with 4 targeted and 12 random biopsies was 10 performed in local anesthesia in an outpatient setting. As fusion biopsy systems ...
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