Two methods to study the primary freeze-drying behavior of bulky solids
are presented, namely, lyomicroscopy and neutron imaging. The
applicability of both methods to visualize the evolution of the
sublimation front is tested for maltodextrin particles with different
sizes and solid concentrations. Exemplary results for both methods are
reported and the applicability of both methods to study freeze-drying
behavior of bulk solids is described. To estimate the impact of particle
size and bed height for the freeze-drying of bulky solids, a modified
Biot number is introduced to estimate the optimum particle size for a
given bed height and formulation. The applicability of the two methods
with regard to the modified Biot numbers is discussed.
«
Two methods to study the primary freeze-drying behavior of bulky solids
are presented, namely, lyomicroscopy and neutron imaging. The
applicability of both methods to visualize the evolution of the
sublimation front is tested for maltodextrin particles with different
sizes and solid concentrations. Exemplary results for both methods are
reported and the applicability of both methods to study freeze-drying
behavior of bulk solids is described. To estimate the impact of particle...
»