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Title:

Integrative analysis reveals early and distinct genetic and epigenetic changes in intraductal papillary and tubulopapillary cholangiocarcinogenesis.

Document type:
Journal Article
Author(s):
Goeppert, Benjamin; Stichel, Damian; Toth, Reka; Fritzsche, Sarah; Loeffler, Moritz Anton; Schlitter, Anna Melissa; Neumann, Olaf; Assenov, Yassen; Vogel, Monika Nadja; Mehrabi, Arianeb; Hoffmann, Katrin; Köhler, Bruno; Springfeld, Christoph; Weichenhan, Dieter; Plass, Christoph; Esposito, Irene; Schirmacher, Peter; von Deimling, Andreas; Roessler, Stephanie
Abstract:
OBJECTIVE: A detailed understanding of the molecular alterations in different forms of cholangiocarcinogenesis is crucial for a better understanding of cholangiocarcinoma (CCA) and may pave the way to early diagnosis and better treatment options. DESIGN: We analysed a clinicopathologically well-characterised patient cohort (n=54) with high-grade intraductal papillary (IPNB) or tubulopapillary (ITPN) neoplastic precursor lesions of the biliary tract and correlated the results with an independent...     »
Journal title abbreviation:
Gut
Year:
2022
Journal volume:
71
Journal issue:
2
Pages contribution:
391-401
Fulltext / DOI:
doi:10.1136/gutjnl-2020-322983
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33468537
Print-ISSN:
0017-5749
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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