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Titel:

2-O-beta-D-Glucopyranosyl-carboxyatractyligenin from Coffea L. inhibits adenine nucleotide translocase in isolated mitochondria but is quantitatively degraded during coffee roasting

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Lang, Roman; Fromme, Tobias; Beusch, Anja; Wahl, Anika; Klingenspor, Martin; Hofmann, Thomas
Abstract:
Atractyloside (1) and carboxyatractyloside (2) are well-known inhibitors of the adenine nucleotide translocase (ANT) in mitochondria, thus effectively blocking oxidative phosphorylation. Structurally related derivatives atractyligenin (3), 2-O-beta-D-glucopyranosyl-atractyligenin (4), 3'-O-beta-D-glucopyranosyl-2'-O-isovaleryl-2beta-(2-desoxy-atractyligenin)-beta-D -glucopyranoside (5), and 2-O-beta-D-glucopyranosyl-carboxyatractyligenin (6) were isolated from raw beans of Coffea L. and the impa...     »
Zeitschriftentitel:
Phytochemistry
Jahr:
2013
Band / Volume:
93
Seitenangaben Beitrag:
124--135
Volltext / DOI:
doi:10.1016/j.phytochem.2013.03.022
Print-ISSN:
0031-9422
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