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Title:

Multifunctional rapidly adapting mechanosensitive enteric neurons ({RAMEN}) in the myenteric plexus of the guinea pig ileum.

Document type:
Zeitschriftenaufsatz
Author(s):
Mazzuoli, Gemma; Schemann, Michael
Abstract:
An important feature of the enteric nervous system (ENS) is its capability to respond to mechanical stimulation which, as currently suggested for the guinea-pig ileum, is encoded by specialized intrinsic primary afferent neurons (IPANs). We used von Frey hairs or intraganglionic volume injections to mimic ganglion deformation as observed in freely contracting preparations. Using fast voltage-sensitive dye imaging we identified rapidly adapting mechanosensitive enteric neurons (RAMEN, 25% of all...     »
Keywords:
Action Potentials, Physical Stimulation, Fluorescent Dyes, Pyridinium Compounds, Animals, Guinea Pigs, Male, Mechanoreceptors/*physiology, Electrophysiological Phenomena, Ganglia/physiology, Ileum/*innervation, Interneurons/physiology, Models, Neurological, Motor Neurons/physiology, Myenteric Plexus/*cytology/*physiology, Tissue Culture Techniques
Journal title:
The Journal of physiology
Year:
2009
Journal volume:
587
Month:
oct
Journal issue:
Pt 19
Pages contribution:
4681--4694
Language:
eng
Fulltext / DOI:
doi:10.1113/jphysiol.2009.177105
Print-ISSN:
1469-7793 0022-3751
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