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Title:

The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma.

Document type:
Journal Article; 1
Author(s):
Lenk, Lennart; Pein, Maren; Will, Olga; Gomez, Beatriz; Viol, Fabrice; Hauser, Charlotte; Egberts, Jan-Hendrik; Gundlach, Jan-Paul; Helm, Ole; Tiwari, Sanjay; Weiskirchen, Ralf; Rose-John, Stefan; Röcken, Christoph; Mikulits, Wolfgang; Wenzel, Patrick; Schneider, Günter; Saur, Dieter; Schäfer, Heiner; Sebens, Susanne
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed when liver metastases already emerged. This study elucidated the impact of hepatic stromal cells on growth behavior of premalignant and malignant pancreatic ductal epithelial cells (PDECs). Liver sections of tumor-bearing KPC mice comprised micrometastases displaying low proliferation located in an unobtrusive hepatic microenvironment whereas macrometastases containing more proliferating cells were surrounded by hepatic myofibroblasts (H...     »
Journal title abbreviation:
Oncoimmunology
Year:
2017
Journal volume:
7
Journal issue:
1
Pages contribution:
e1368603
Language:
eng
Fulltext / DOI:
doi:10.1080/2162402X.2017.1368603
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29296518
Print-ISSN:
2162-4011
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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