Benutzer: Gast  Login
Titel:

Ductal obstruction promotes formation of preneoplastic lesions from the pancreatic ductal compartment.

Dokumenttyp:
Journal Article
Autor(en):
Cheng, Tao; Zhang, Zhiheng; Jian, Ziying; Raulefs, Susanne; Schlitter, Anna Melissa; Steiger, Katja; Maeritz, Nadja; Zhao, Yamin; Shen, Shanshan; Zou, Xiaoping; Ceyhan, Güralp O; Friess, Helmut; Kleeff, Jörg; Michalski, Christoph W; Kong, Bo
Abstract:
Pancreatitis is a significant risk factor for pancreatic ductal adenocarcinoma (PDAC). Previous studies in mice have demonstrated that pancreatitis contributes to oncogenic Kras-driven carcinogenesis, probably initiated in acinar cells; however, oncogenic Kras alone or in combination with caerulein-induced pancreatitis is not sufficient in initiating PDAC from the ductal compartment. We thus introduced ductal obstruction - which induces a more severe form of pancreatitis - by pancreatic ductal...     »
Zeitschriftentitel:
Int J Cancer
Jahr:
2019
Band / Volume:
144
Heft / Issue:
10
Seitenangaben Beitrag:
2529-2538
Sprache:
eng
Volltext / DOI:
doi:10.1002/ijc.31981
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30412288
Print-ISSN:
0020-7136
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
 BibTeX