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Title:

BACE inhibition-dependent repair of Alzheimer's pathophysiology.

Document type:
Journal Article; Article
Author(s):
Keskin, Aylin D; Keku?, Maja; Adelsberger, Helmuth; Neumann, Ulf; Shimshek, Derya R; Song, Beomjong; Zott, Benedikt; Peng, Tingying; Förstl, Hans; Staufenbiel, Matthias; Nelken, Israel; Sakmann, Bert; Konnerth, Arthur; Busche, Marc Aurel
Abstract:
Amyloid-? (A?) is thought to play an essential pathogenic role in Alzheimer´s disease (AD). A key enzyme involved in the generation of A? is the ?-secretase BACE, for which powerful inhibitors have been developed and are currently in use in human clinical trials. However, although BACE inhibition can reduce cerebral A? levels, whether it also can ameliorate neural circuit and memory impairments remains unclear. Using histochemistry, in vivo Ca2+ imaging, and behavioral analyses in a mouse model...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2017
Journal volume:
114
Journal issue:
32
Pages contribution:
8631-8636
Language:
eng
Fulltext / DOI:
doi:10.1073/pnas.1708106114
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28739891
Print-ISSN:
0027-8424
TUM Institution:
Institut für Neurowissenschaften; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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