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Title:

Conditional genetic deletion of Ano1 in interstitial cells of Cajal impairs Ca transients and slow waves in adult mouse small intestine.

Document type:
Journal Article; 3
Author(s):
Malysz, John; Gibbons, Simon J; Saravanaperumal, Siva A; Du, Peng; Eisenman, Seth T; Cao, Chike; Oh, Uhtaek; Saur, Dieter; Klein, Sabine; Ordog, Tamas; Farrugia, Gianrico
Abstract:
Myenteric plexus interstitial cells of Cajal (ICC-MY) in the small intestine are Kit electrical pacemakers that express the Ano1/TMEM16A Ca-activated Cl channel, whose functions in the gastrointestinal tract remain incompletely understood. In this study, an inducible Cre-LoxP-based approach was used to advance the understanding of Ano1 in ICC-MY of adult mouse small intestine. mice were treated with tamoxifen or vehicle, and small intestines (mucosa free) were examined. Quantitative RT-PCR demo...     »
Journal title abbreviation:
Am J Physiol Gastrointest Liver Physiol
Year:
2017
Journal volume:
312
Journal issue:
3
Pages contribution:
G228-G245
Language:
eng
Fulltext / DOI:
doi:10.1152/ajpgi.00363.2016
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27979828
Print-ISSN:
0193-1857
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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