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Title:

Spatial investigation of the elemental distribution in Wilson's disease liver after d-penicillamine treatment by LA-ICP-MS.

Document type:
Journal Article
Author(s):
Hachmöller, Oliver; Zibert, Andree; Zischka, Hans; Sperling, Michael; Groba, Sara Reinartz; Grünewald, Inga; Wardelmann, Eva; Schmidt, Hartmut H-J; Karst, Uwe
Abstract:
At present, the copper chelator d-penicillamine (DPA) is the first-line therapy of Wilson's disease (WD), which is characterized by an excessive copper overload. Lifelong DPA treatments aim to reduce the amount of detrimental excess copper retention in the liver and other organs. Although DPA shows beneficial effect in many patients, it may cause severe adverse effects. Despite several years of copper chelation therapy, discontinuation of DPA therapy can be linked to a rapidly progressing liver...     »
Journal title abbreviation:
J Trace Elem Med Biol
Year:
2017
Journal volume:
44
Pages contribution:
26-31
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jtemb.2017.05.008
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28965585
Print-ISSN:
0946-672X
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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