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Titel:

Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model.

Dokumenttyp:
Journal Article; Article
Autor(en):
Romanelli, Elisa; Merkler, Doron; Mezydlo, Aleksandra; Weil, Marie-Theres; Weber, Martin S; Niki?, Ivana; Potz, Stephanie; Meinl, Edgar; Matznick, Florian E H; Kreutzfeldt, Mario; Ghanem, Alexander; Conzelmann, Karl-Klaus; Metz, Imke; Brück, Wolfgang; Routh, Matthew; Simons, Mikael; Bishop, Derron; Misgeld, Thomas; Kerschensteiner, Martin
Abstract:
Oligodendrocyte damage is a central event in the pathogenesis of the common neuroinflammatory condition, multiple sclerosis (MS). Where and how oligodendrocyte damage is initiated in MS is not completely understood. Here, we use a combination of light and electron microscopy techniques to provide a dynamic and highly resolved view of oligodendrocyte damage in neuroinflammatory lesions. We show that both in MS and in its animal model structural damage is initiated at the myelin sheaths and only l...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2016
Band / Volume:
7
Seitenangaben Beitrag:
13275
Sprache:
eng
Volltext / DOI:
doi:10.1038/ncomms13275
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27848954
Print-ISSN:
2041-1723
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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