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Titel:

Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro.

Dokumenttyp:
Journal Article
Autor(en):
Xia, Yuchen; Cheng, Xiaoming; Blossey, Christoph K; Wisskirchen, Karin; Esser, Knud; Protzer, Ulrike
Abstract:
Interferon- (IFN-) has been used for more than 20 years as the first-line therapy for hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, because it has a number of antiviral effects. In this study, we describe a novel mode of its antiviral action. We demonstrate that the supernatant from IFN--treated cultured cells restricted HBV and HCV infection by inhibiting viral entry into hepatoma cells. The factors contained in the supernatant competed with the virus for binding to heparan gly...     »
Zeitschriftentitel:
J Immunol Res
Jahr:
2017
Band / Volume:
2017
Seitenangaben Beitrag:
4828936
Sprache:
eng
Volltext / DOI:
doi:10.1155/2017/4828936
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28367455
Print-ISSN:
2314-8861
TUM Einrichtung:
Institut für Virologie
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