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Titel:

Short-term, but not post-exposure, protection against lethal orthopoxvirus challenge after immunization with modified vaccinia virus Ankara.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Staib, C; Suezer, Y; Kisling, S; Kalinke, U; Sutter, G
Abstract:
Safety-tested vaccinia virus (VACV) MVA serves as a candidate third-generation vaccine against smallpox. Here, MVA immunization of mice shortly before or after lethal respiratory challenge with VACV Western Reserve was investigated. Whilst post-exposure treatment failed to protect animals, immunizations on day 2 prior to challenge were fully protective. On the day of challenge, MVA inoculation may prevent death, but not onset of severe respiratory disease. After intranasal MVA application, massi...     »
Zeitschriftentitel:
J Gen Virol
Jahr:
2006
Band / Volume:
87
Heft / Issue:
Pt 10
Seitenangaben Beitrag:
2917-21
Sprache:
eng
Volltext / DOI:
doi:10.1099/vir.0.82068-0
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16963750
Print-ISSN:
0022-1317
TUM Einrichtung:
Institut für Virologie
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