Benutzer: Gast  Login
Titel:

Human papillomavirus type 16 L1 capsomeres induce L1-specific cytotoxic T lymphocytes and tumor regression in C57BL/6 mice.

Dokumenttyp:
Journal Article
Autor(en):
Ohlschläger, P; Osen, W; Dell, K; Faath, S; Garcea, RL; Jochmus, I; Muller, M; Pawlita, M; Schäfer, K; Sehr, P; Staib, C; Sutter, G; Gissmann, L
Abstract:
We analyzed capsomeres of human papillomavirus type 16 (HPV16) consisting of the L1 major structural protein for their ability to trigger a cytotoxic T-cell (CTL) response. To this end, we immunized C57BL/6 mice and used the L1(165-173) peptide for ex vivo restimulation of splenocytes prior to analysis ((51)Cr release assay and enzyme-linked immunospot assay [ELISPOT]). This peptide was identified in this study as a D(b)-restricted naturally processed CTL epitope by HPV16 L1 sequence analysis, m...     »
Zeitschriftentitel:
J Virol
Jahr:
2003
Band / Volume:
77
Heft / Issue:
8
Seitenangaben Beitrag:
4635-45
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12663770
Print-ISSN:
0022-538X
TUM Einrichtung:
Institut für Virologie
 BibTeX