Neurotrophin-mediated rapid signaling in the central nervous system: mechanisms and functions.

Title:: Neurotrophin-mediated rapid signaling in the central nervous system: mechanisms and functions.
Document type:: Journal Article; Review; Review
Author(s):: Blum, R; Konnerth, A
Abstract:: Neurotrophins regulate growth, survival, and differentiation of central neurons. In addition to the "classical" effects that are relatively slow neurotrophins also elicit rapid signaling that modulates a variety of cellular functions such as membrane excitability, synaptic transmission, and activity-dependent synaptic plasticity. These rapid actions are mediated mainly through the interaction of Trk receptors with ion channels and ionotropic receptors in the plasma membrane.
Journal title abbreviation:: Physiology (Bethesda)
Year:: 2005
Journal volume:: 20
Pages contribution:: 70-8
Language:: eng
Fulltext / DOI:: doi:10.1152/physiol.00042.2004
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/15653842
Print-ISSN:: 1548-9213
TUM Institution:: Institut für Neurowissenschaften
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