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Titel:

Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Wingender, G; Garbi, N; Schumak, B; Jüngerkes, F; Endl, E; von Bubnoff, D; Steitz, J; Striegler, J; Moldenhauer, G; Tüting, T; Heit, A; Huster, KM; Takikawa, O; Akira, S; Busch, DH; Wagner, H; Hämmerling, GJ; Knolle, PA; Limmer, A
Abstract:
CpG-rich oligonucleotides (CpG-ODN) bind to Toll-like receptor 9 (TLR9) and are used as powerful adjuvants for vaccination. Here we report that CpG-ODN not only act as immune stimulatory agents but can also induce strong immune suppression depending on the anatomical location of application. In agreement with the adjuvant effect, subcutaneous application of antigen plus CpG-ODN resulted in antigen-specific T cell activation in local lymph nodes. In contrast, systemic application of CpG-ODN resul...     »
Zeitschriftentitel:
Eur J Immunol
Jahr:
2006
Band / Volume:
36
Heft / Issue:
1
Seitenangaben Beitrag:
12-20
Sprache:
eng
Volltext / DOI:
doi:10.1002/eji.200535602
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16323249
Print-ISSN:
0014-2980
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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