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Titel:

Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney.

Dokumenttyp:
Journal Article
Autor(en):
Leemans, JC; Stokman, G; Claessen, N; Rouschop, KM; Teske, GJ; Kirschning, CJ; Akira, S; van der Poll, T; Weening, JJ; Florquin, S
Abstract:
TLRs are conserved pattern recognition receptors that detect motifs of pathogens and host material released during injury. For unknown reasons, renal TLR2 mRNA is mainly expressed by tubular cells and is enhanced upon renal ischemia/reperfusion (I/R) injury. We evaluated the role of TLR2 in I/R injury using TLR2-/- and TLR2+/+ mice, TLR2 antisense oligonucleotides, and chimeric mice deficient in leukocyte or renal TLR2. Tubular cells needed TLR2 to produce significant cytokine and chemokine amou...     »
Zeitschriftentitel:
J Clin Invest
Jahr:
2005
Band / Volume:
115
Heft / Issue:
10
Seitenangaben Beitrag:
2894-903
Sprache:
eng
Volltext / DOI:
doi:10.1172/JCI22832
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16167081
Print-ISSN:
0021-9738
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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