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Titel:

On the species-specific biotransformation of dibenzo[a,l]pyrene.

Dokumenttyp:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Schober, W; Luch, A; Soballa, VJ; Raab, G; Stegeman, JJ; Doehmer, J; Jacob, J; Seidel, A
Abstract:
We were aimed at investigating the activation of the carcinogenic polycyclic aromatic hydrocarbon (PAH) dibenzo[a,l]pyrene (DB[a,l]P) in Chinese hamster V79 cells that express single human, rat or fish cytochrome P450 (CYP) enzymes. DB[a,l]P is detectable in environmental samples and has been characterized as the most potent carcinogenic species among all PAHs as yet tested in rodent bioassays. Metabolite profiles and metabolite-dependent cytotoxic and clastogenic activities were monitored. The...     »
Zeitschriftentitel:
Chem Biol Interact
Jahr:
2006
Band / Volume:
161
Heft / Issue:
1
Seitenangaben Beitrag:
37-48
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.cbi.2006.02.007
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16581046
Print-ISSN:
0009-2797
TUM Einrichtung:
Klinik und Poliklinik für Dermatologie und Allergologie
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