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Titel:

Activation of human mast cells by aggregated IgG through FcgammaRI: additive effects of C3a.

Dokumenttyp:
Journal Article; Article
Autor(en):
Woolhiser, MR; Brockow, K; METCALFE, DD
Abstract:
Human mast cells (huMC) increase surface expression of FcgammaRI (CD64) in response to IFNgamma. Subsequent receptor aggregation of FcgammaR1 using CD64-specific F(ab')(2) or antibody directed against FcgammaR1-bound IgG results in cell activation. Human mast cells may be observed degranulating in inflammation associated with autoimmune disease and where IFNgamma is produced. We sought to determine if human mast cells cultured in IFNgamma would degranulate in response to aggregated IgG, what med...     »
Zeitschriftentitel:
Clin Immunol
Jahr:
2004
Band / Volume:
110
Heft / Issue:
2
Seitenangaben Beitrag:
172-80
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.clim.2003.11.007
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15003814
Print-ISSN:
1521-6616
TUM Einrichtung:
Klinik und Poliklinik für Dermatologie und Allergologie
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