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Title:

Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney.

Document type:
Journal Article
Author(s):
Leemans, JC; Stokman, G; Claessen, N; Rouschop, KM; Teske, GJ; Kirschning, CJ; Akira, S; van der Poll, T; Weening, JJ; Florquin, S
Abstract:
TLRs are conserved pattern recognition receptors that detect motifs of pathogens and host material released during injury. For unknown reasons, renal TLR2 mRNA is mainly expressed by tubular cells and is enhanced upon renal ischemia/reperfusion (I/R) injury. We evaluated the role of TLR2 in I/R injury using TLR2-/- and TLR2+/+ mice, TLR2 antisense oligonucleotides, and chimeric mice deficient in leukocyte or renal TLR2. Tubular cells needed TLR2 to produce significant cytokine and chemokine amou...     »
Journal title abbreviation:
J Clin Invest
Year:
2005
Journal volume:
115
Journal issue:
10
Pages contribution:
2894-903
Language:
eng
Fulltext / DOI:
doi:10.1172/JCI22832
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16167081
Print-ISSN:
0021-9738
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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