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Titel:

MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Gentner, Bernhard; Pochert, Nicole; Rouhi, Arefeh; Boccalatte, Francesco; Plati, Tiziana; Berg, Tobias; Sun, Su Ming; Mah, Sarah M; Mirkovic-Hösle, Milijana; Ruschmann, Jens; Muranyi, Andrew; Leierseder, Simon; Argiropoulos, Bob; Starczynowski, Daniel T; Karsan, Aly; Heuser, Michael; Hogge, Donna; Camargo, Fernando D; Engelhardt, Stefan; Döhner, Hartmut; Buske, Christian; Jongen-Lavrencic, Mojca; Naldini, Luigi; Humphries, R Keith; Kuchenbauer, Florian
Abstract:
A precise understanding of the role of miR-223 in human hematopoiesis and in the pathogenesis of acute myeloid leukemia (AML) is still lacking. By measuring miR-223 expression in blasts from 115 AML patients, we found significantly higher miR-223 levels in patients with favorable prognosis, whereas patients with low miR-223 expression levels were associated with worse outcome. Furthermore, miR-223 was hierarchically expressed in AML subpopulations, with lower expression in leukemic stem cell-con...     »
Zeitschriftentitel:
Exp Hematol
Jahr:
2015
Band / Volume:
43
Heft / Issue:
10
Seitenangaben Beitrag:
858-868.e7
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.exphem.2015.05.018
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26163797
Print-ISSN:
0301-472X
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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