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Titel:

Spontaneous Pancreatitis Caused by Tissue-Specific Gene Ablation of Hhex in Mice.

Dokumenttyp:
Journal Article
Autor(en):
Ferreira, Mark J; McKenna, Lindsay B; Zhang, Jia; Reichert, Maximilian; Bakir, Basil; Buza, Elizabeth L; Furth, Emma E; Bogue, Clifford W; Rustgi, Anil K; Kaestner, Klaus H
Abstract:
Perturbations in pancreatic ductal bicarbonate secretion cause chronic pancreatitis. The physiologic mechanism of ductal secretion is known, but its transcriptional control is not. We determine the role of the transcription factor hematopoietically expressed homeobox protein (Hhex) in ductal secretion and pancreatitis.We derived mice with pancreas-specific, Cremediated Hhex gene ablation to determine the requirement of Hhex in the pancreatic duct in early life and in adult stages. Histologic and...     »
Zeitschriftentitel:
Cell Mol Gastroenterol Hepatol
Jahr:
2015
Band / Volume:
1
Heft / Issue:
5
Seitenangaben Beitrag:
550-569
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26740970
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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