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Title:

Spontaneous Pancreatitis Caused by Tissue-Specific Gene Ablation of Hhex in Mice.

Document type:
Journal Article
Author(s):
Ferreira, Mark J; McKenna, Lindsay B; Zhang, Jia; Reichert, Maximilian; Bakir, Basil; Buza, Elizabeth L; Furth, Emma E; Bogue, Clifford W; Rustgi, Anil K; Kaestner, Klaus H
Abstract:
Perturbations in pancreatic ductal bicarbonate secretion cause chronic pancreatitis. The physiologic mechanism of ductal secretion is known, but its transcriptional control is not. We determine the role of the transcription factor hematopoietically expressed homeobox protein (Hhex) in ductal secretion and pancreatitis.We derived mice with pancreas-specific, Cremediated Hhex gene ablation to determine the requirement of Hhex in the pancreatic duct in early life and in adult stages. Histologic and...     »
Journal title abbreviation:
Cell Mol Gastroenterol Hepatol
Year:
2015
Journal volume:
1
Journal issue:
5
Pages contribution:
550-569
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26740970
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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