Compared to standard PET/CT, PET/MR (using MR-based attenuation correction AC) has proven comparability in general, but it may affect brain imaging (group comparisons). Our study evaluated whether inter-methodological effects would apply to diagnostic assessment of individuals examined for cognitive impairment. We employed blinded reads of 3DSSP PET data pairs for each patient (MR and CT-derived) and a systematic single case review. Clinical reading of PET/MR scans was more inaccurate, especially in cases of low-grade pathologies, hampering diagnostic assessment. Optimized AC algorithms and a PET/MR-specific healthy control database are recommended to ensure its consistent application in neuroimaging.
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Compared to standard PET/CT, PET/MR (using MR-based attenuation correction AC) has proven comparability in general, but it may affect brain imaging (group comparisons). Our study evaluated whether inter-methodological effects would apply to diagnostic assessment of individuals examined for cognitive impairment. We employed blinded reads of 3DSSP PET data pairs for each patient (MR and CT-derived) and a systematic single case review. Clinical reading of PET/MR scans was more inaccurate, especiall...
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