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Titel:

?-Conotoxin M1 (CTx) blocks ?? binding sites of adult nicotinic receptors while ACh binding at ?? sites elicits only small and short quantal synaptic currents.

Dokumenttyp:
Journal Article; Article
Autor(en):
Dudel, Josef
Abstract:
In 'embryonic' nicotinic receptors, low CTx concentrations are known to block only the ?? binding site, whereas binding of ACh at the ??-site elicits short single channel openings and short bursts. In adult muscles the ??- is replaced by the ??-site. Quantal EPSCs (qEPSCs) were elicited in adult muscles by depolarization pulses and recorded through a perfused macropatch electrode. One to 200 nmol L(-1) CTx reduced amplitudes and decay time constants of qEPSCs, but increased their rise times. CTx...     »
Zeitschriftentitel:
Physiol Rep
Jahr:
2014
Band / Volume:
2
Heft / Issue:
12
Sprache:
eng
Volltext / DOI:
doi:10.14814/phy2.12188
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25501436
TUM Einrichtung:
Institut für Neurowissenschaften
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