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Title:

Polymorphic variants of adrenoceptors: pharmacology, physiology, and role in disease.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Ahles, Andrea; Engelhardt, Stefan
Abstract:
The human genome encodes nine different adrenoceptor genes. These are grouped into three families, namely, the ?1-, ?2-, and ?-adrenoceptors, with three family members each. Adrenoceptors are expressed by most cell types of the human body and are primary targets of the catecholamines epinephrine and norepinephrine that are released from the sympathetic nervous system during its activation. Upon catecholamine binding, adrenoceptors change conformation, couple to and activate G proteins, and there...     »
Journal title abbreviation:
Pharmacol Rev
Year:
2014
Journal volume:
66
Journal issue:
3
Pages contribution:
598-637
Language:
eng
Fulltext / DOI:
doi:10.1124/pr.113.008219
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24928328
Print-ISSN:
0031-6997
TUM Institution:
Institut für Pharmakologie und Toxikologie
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