The present study hypothesizes that there is an association between headache and anatomical regions of the brain involved in acute ischemic stroke. Voxel-based overlay and subtraction plots showed a strong association between headache symptoms and ischemic lesions in the insular cortex and the somatosensory cortex. This was confirmed in a reflection analysis with solely right-sided lesions and with a non-parametric statistical analysis. The association with the insular cortex, which is a well-established area of pain processing, suggests a central cause of headache symptoms with stroke.
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The present study hypothesizes that there is an association between headache and anatomical regions of the brain involved in acute ischemic stroke. Voxel-based overlay and subtraction plots showed a strong association between headache symptoms and ischemic lesions in the insular cortex and the somatosensory cortex. This was confirmed in a reflection analysis with solely right-sided lesions and with a non-parametric statistical analysis. The association with the insular cortex, which is a well-es...
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