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Title:

Tetraspanin CD63 acts as a pro-metastatic factor via ?-catenin stabilization.

Document type:
journal article
Author(s):
Seubert, Bastian, B; Cui, Haissi, H; Simonavicius, Nicole, N; Honert, Katja, K; Schäfer, Sandra, S; Reuning, Ute, U; Heikenwalder, Mathias, M; Mari, Bernard, B; Krüger, Achim, A
Abstract:
The tetraspanin CD63 is implicated in pro-metastatic signaling pathways but, so far, it is unclear, how CD63 levels affect the tumor cell phenotype. Here, we investigated the effect of CD63 modulation in different metastatic tumor cell lines. In vitro, knock down of CD63 induced a more epithelial-like phenotype concomitant with increased E-cadherin expression, downregulation of its repressors Slug and Zeb1, and decreased N-cadherin. In addition, ?-catenin protein was markedly reduced, negatively...     »
Journal title abbreviation:
Int J Cancer
Year:
2014
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25354204
Print-ISSN:
0020-7136
TUM Institution:
Institut für Virologie ; Frauenklinik und Poliklinik
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