Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms.

Titel:: Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms.
Dokumenttyp:: Journal Article
Autor(en):: Klöppel, G
Abstract:: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are composed of cells with a neuroendocrine phenotype. The old and the new WHO classifications distinguish between well-differentiated and poorly differentiated neoplasms. All well-differentiated neoplasms, regardless of whether they behave benignly or develop metastases, will be called neuroendocrine tumours (NETs), and graded G1 (Ki67 <2%) or G2 (Ki67 2-20%). All poorly differentiated neoplasms will be termed neuroendocrine carcinomas (NECs) and graded G3 (Ki67 >20%). To stratify the GEP-NETs and GEP-NECs regarding their prognosis, they are now further classified according to TNM-stage systems that were recently proposed by the European Neuroendocrine Tumour Society (ENETS) and the AJCC/UICC. In the light of these criteria the pathology and biology of the various NETs and NECs of the gastrointestinal tract (including the oesophagus) and the pancreas are reviewed.
Zeitschriftentitel:: Endocr Relat Cancer
Jahr:: 2011
Band / Volume:: 18 Suppl 1
Seitenangaben Beitrag:: S1-S16
Sprache:: eng
Volltext / DOI:: doi:10.1530/ERC-11-0013
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/22005112
Print-ISSN:: 1351-0088
TUM Einrichtung:: Institut für Allgemeine Pathologie und Pathologische Anatomie
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